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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCR
All Species:
40.61
Human Site:
S146
Identified Species:
63.81
UniProt:
P04035
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P04035
NP_000850.1
888
97476
S146
T
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
Chimpanzee
Pan troglodytes
XP_001148324
888
97313
S146
T
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
Rhesus Macaque
Macaca mulatta
XP_001104607
888
97210
S146
A
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
Dog
Lupus familis
XP_536323
888
97475
S146
A
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
Cat
Felis silvestris
Mouse
Mus musculus
Q01237
887
97003
S146
A
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
Rat
Rattus norvegicus
P51639
887
96670
S146
A
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_989816
875
95421
E145
L
S
S
N
S
Q
D
E
V
R
E
N
I
S
R
Frog
Xenopus laevis
P20715
883
96702
S146
A
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
Zebra Danio
Brachydanio rerio
NP_001119931
893
97691
S146
A
L
A
K
F
A
L
S
S
N
S
Q
D
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P14773
920
98299
S191
R
L
A
Q
L
A
L
S
G
S
N
Q
A
E
V
Honey Bee
Apis mellifera
XP_623118
908
99432
S148
V
L
A
Q
L
A
L
S
S
R
N
K
E
E
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
P16393
932
100947
S147
A
L
T
K
F
A
L
S
S
T
T
Q
N
E
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24594
579
60912
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P14891
592
63579
Baker's Yeast
Sacchar. cerevisiae
P12683
1054
115607
E277
K
I
A
Q
Y
A
L
E
K
F
E
R
V
G
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.7
95.7
N.A.
93.3
92.7
N.A.
N.A.
85.1
80.9
77.8
N.A.
47.2
51.2
N.A.
56.3
Protein Similarity:
100
99.7
99.3
97.3
N.A.
96
95.8
N.A.
N.A.
91.6
89.5
86.7
N.A.
64.6
69.2
N.A.
70.6
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
0
93.3
93.3
N.A.
53.3
53.3
N.A.
66.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
6.6
93.3
93.3
N.A.
73.3
80
N.A.
80
Percent
Protein Identity:
N.A.
33.5
N.A.
34.5
35.1
N.A.
Protein Similarity:
N.A.
46.8
N.A.
47.5
51
N.A.
P-Site Identity:
N.A.
0
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
0
N.A.
0
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
0
74
0
0
80
0
0
0
0
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
7
0
0
0
0
0
54
0
0
% D
% Glu:
0
0
0
0
0
0
0
14
0
0
14
0
7
74
0
% E
% Phe:
0
0
0
0
60
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% I
% Lys:
7
0
0
60
0
0
0
0
7
0
0
7
0
0
0
% K
% Leu:
7
74
0
0
14
0
80
0
0
0
0
0
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
0
0
54
14
7
7
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
20
0
7
0
0
0
0
0
67
0
0
0
% Q
% Arg:
7
0
0
0
0
0
0
0
0
14
0
7
0
0
7
% R
% Ser:
0
7
7
0
7
0
0
74
67
7
54
0
0
7
0
% S
% Thr:
14
0
7
0
0
0
0
0
0
7
7
0
0
0
0
% T
% Val:
7
0
0
0
0
0
0
0
7
0
0
0
7
0
74
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _